Healthy Subjects Needed For A Grapefruit Juice-Drug Interaction Study
About the event
HEALTHY SUBJECTS NEEDED FOR A GRAPEFRUIT JUICE-DRUG INTERACTION STUDY
This study will advance the development of an improved antidote for excess drug levels due to overdose or consumption with grapefruit juice
This study will evaluate the ability of a nasal formulation of an antidote (naloxone, Narcan®) to the effects of a narcotic (alfentanil, Alfenta®) in the absence and presence of grapefruit juice. Enrolled individuals will receive a single dose of alfentanil by mouth on 6 different occasions. They will receive a glass of water (1st, 2nd, and 3rd occasion) or grapefruit juice (4th, 5th, and 6th occasion) before alfentanil. They will receive naloxone injected into the muscle (2nd and 5th occasion) or through a nasal spray (3rd and 6th occasion). Subjects also will receive a medical exam and will undergo routine blood and urine laboratory tests.
Study subjects will receive
- up to $500 for their participation
You may be eligible to take part in this study if you
- are 18-40 years old,
- are not taking any medications or dietary supplements that can interfere with your ability to eliminate the study drugs, and
- have the time to participate
You will not be eligible to take part in this study if you
- have a chronic illness,
- have a hematologic (blood) disorder,
- have a history of drug or alcohol abuse,
- have any major psychiatric illness,
- have the need or have used opioid analgesics three weeks prior to the study,
- have a history of allergy to alfentanil (or other opioid analgesic), naloxone, or grapefruit juice
- have any nasal (nose) problems, or
- are a woman and are pregnant or breastfeeding
The Washington State University College of Pharmacy is conducting this research through funding provided by the National Institutes of Health and the College of Pharmacy.
For information about this study, please contact: Mary F. Paine, RPh, PhD; 509-358-7759; mary.paine@wsu.edu
The WSU IRB has reviewed and approved this research project for human subject participation.
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